Jean Lafitte National Historical Park and Preserve was established to preserve signifcant examples of the rich natural and cultural resources of Louisiana's Mississippi Delta region. The park seeks to illustrate the influence of environment and history on the development of a unique regional culture. The park consists of six physically separate sites and a park headquarters located in southeastern Louisiana. The sites in Lafayette, Thibodaux, and Eunice interpret the Acadian culture of the area. The Barataria Preserve (in Marrero) interprets the natural and cultural history of the uplands, swamps, and marshlands of the region. Six miles southeast of New Orleans is the Chalmette Battlefield and National Cemetery, site of the 1815 Battle of New Orleans and the final resting place for soldiers from the Civil War, Spanish-American War, World Wars I and II, and Vietnam. At 419 Decatur Street in the historic French Quarter is the park's visitor center for New Orleans. This center interprets the history of New Orleans and the diverse cultures of Louisiana's Mississippi Delta region. The Park Headquarters is located in New Orleans.

Cane River Creole National Historical Park is located within the Cane River National Heritage Area in Natchitoches Parish, Louisiana. The park includes 44.16 acres of Oakland Plantation and 18.75 acres of Magnolia Plantation. The two park sites include a total of 67 historic structures remnant from 200 years of plantation life.

Located in northeastern Louisiana, this park commemorates a culture that thrived during the first and second millennia B.C. This site, which contains some of the largest prehistoric earth works in North America, is managed by the state of Louisiana.